General Clinical Chemistry Analyzers and Accessories
AdipoGen Sodium tetrap-tolylborate
Chemical. CAS 15738-23-5. Formula C28H28BNa. MW 398.32. Synthetic. Analytical/Chromatography reagent. Ion sensor compound. Additive for ISE.
Abcam SB-525334, TGFBR1 inhibitor., 25MG
MW 343.4 Da, Purity >98%. Cell permeable, potent, selective transforming growth factor beta 1 receptor (ALK5) (IC₅₀ = 14.3 nM) and ALK4 (IC₅₀ = 58.5 nM) inhibitor, with no activity at ALK2, 3 and 6 (IC₅₀ > 10 μM). Blocks fibrosis and renal injury markers in a puromycin-induced nephritis model. Causes significant attenuation in Smad2/3 nuclear translocation and a decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam URMC-099, 25MG
MW 421.5 Da, Purity >98%. Novel orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor (IC₅₀ values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively). Inhibits multiple kinase pathways including LRRK2 (IC₅₀ = 11 nM). Decreases the production of inflammatory cytokines in cultured microglia exposed to HIV-1 Tat. Reduces fMLP-induced chemotaxis of neutrophil from wild-type C57Bl/6 mice. Facilitates Amyloid-β Clearance in a Murine Model of Alzheimer's Disease.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ispinesib (SB-715992), 10MG
MW 517.1 Da, Purity >98%. A potent, selective and reversible allosteric inhibitor of KSP with IC₅₀ value of 0.5 nM. Often combines with chemotherapy drugs to tumor treatment.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Rhodamine 6G hexanediamine ami
Chemical. CAS 1140505-40-3. Formula C32H40N4O2 . C4H2F6O4. MW 740.73. Synthetic. N-6-Aminohexylrhodamine 6G-amide bistrifluoroacetate is a rhodamine 6G-amide derivative useful as a bioreagent in fluorescence assays.
Abcam WH-4-023, 5MG
MW 568.7 Da, Purity >98%. Potent and selective inihbitor of the tyrosine kinases Lck and Src with IC₅₀ values of 2 nM for Lck and 6 nM for Src.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 2', 7'-Dichlorofluorescein di-ß-D-lactoside, 5MG
MW 1049.76 g/mol. Highly sensitive fluorescent substrate for measuring beta-lactosidase and glucosidase inside live cells. Retains fluorescence at low pH due to lower pKa than comparable fluorophores. Suitable for measuring activity in the acidic lysosome environment.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Cyflufenamid
Chemical. CAS 180409-60-3. Formula C20H17F5N2O2. MW 412.36. Synthetic Amidoxime fungicide used in agroculture. Active against powdery mildew of various crops in pre and post infection treatment. Has a long lasting translaminar and vapor phase activity. The mode of action is not know and it is considered different from that of other existing fungicides. It has favorable toxicological, ecotoxicological and environmental profiles. Compound can be used as analytical reference material.
Abcam WAY-316606, 1MG
MW 448.5 Da, Purity >=98%. A secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM). It blocks sFRP-1 from interacting with Wnt and thus increases Wnt signaling.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist, 100MG
MW 485.5 Da. Potent and selective Smoothened antagonist. Blocks Hedgehog signaling pathway activity (IC₅₀ = 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays. Anti-tumor activity in mouse medulloblastoma allograft model.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SP-2509, LSD1 inhibitor, 25MG
MW 437.9 Da, Purity >98%. Potent, selective (IC₅₀ = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A). No activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ganetespib (STA-9090), 25MG
MW 364.4 Da, Purity >98%. Potent Hsp90 inhibitor (IC₅₀ of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC₅₀ of 43 nM.
The product is subject to the following: Abcam Restricted Use Statement
Abcam E7820, 5MG
MW 336.4 Da, Purity >=98%. A small molecule sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells. Inhibition of integrin alpha 2 leads to an inhibition of cell-cell interactions, endothelial cell-matrix interactions, vascular endothelial cell proliferation and angiogenesis.
The product is subject to the following: Abcam Restricted Use Statement
